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Calcium-binding proteins are proteins that participate in calcium cell signalling pathways by binding to Ca2+. Many different calcium-binding proteins exist, with different cellular and tissue distribution and involvement in specific functions.〔 〕 The most ubiquitous Ca2+-sensing protein, found in all eukaryotic organisms including yeasts, is calmodulin. Intracellular storage and release of Ca2+ from the sarcoplasmic reticulum is associated with the high-capacity, low-affinity calcium-binding protein calsequestrin.〔Siegel, George (Ed.). ''Basic neurochemistry: molecular, cellular and medical aspects''. Lippincott Williams and Wilkins / 1999 ISBN 0-397-51820-X〕 With their role in signal transduction, calcium-binding proteins contribute to all aspects of the cell's functioning, from homeostasis to learning and memory. For example, the neuron-specific calexcitin has been found to have an excitatory effect on neurons, and interacts with proteins that control the firing state of neurons, such as the voltage-dependent potassium channel. Compartmentalization of calcium binding proteins has been noted within cells, suggesting that these proteins perform distinct functions in localized calcium signaling. It also indicates that in addition to freely diffusing through the cytoplasm to attain a homogeneous distribution, calcium binding proteins can bind to cellular structures through interactions that are likely important for their functions.〔 ==See also== *calmodulin *calsequestrin *Vitamin D-dependent calcium-binding protein 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Calcium-binding protein」の詳細全文を読む スポンサード リンク
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